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This reprogramming can lead to improved metabolic health, reduced inflammation, and enhanced resistance to diseases such as cancer 12

All-trans retinoic acid (ATRA), the active form of vitamin A, binds to nuclear retinoic acid receptors (RAR//), regulating various biological processes, such as cell proliferation, differentiation, and apoptosis (30)

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Due to their intrinsic characteristics, such as high energy needs to support heightened basal oxidative phosphorylation in the mitochondria, high axon terminal density, and substantial axonal arborization, dopaminergic neurons are particularly susceptible to degeneration

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