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Reported side effects include water retention, flushing, headache, tingling in the extremities, elevated IGF-1 levels, impaired glucose tolerance, and injection site reactions including pain and infection risk

Among them, GIF-2114 and GIF-2 197-r), the two compounds with the highest activity, have the same neuroprotective ability as Fer-1 on cell death induced by glutamate and Erastin at sub-nano molar concentration

The deficiency in the production of glutathione leads to break down of red blood cells, enlargement of the spleen, gallstones,and after many years can lead to mental deterioration.*

Reconstituted stability: 24 weeks refrigerated

[DOI] [PubMed] [Google Scholar] 2.Milder J, Patel M