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In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

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Bioglutide: GI adverse events predominantly mild or comparable between treatment and placebo arms

It also has effects on appetite, libido, and other melanocortin-mediated pathways