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These models allow researchers to zero in on and study the target TSH receptor, thyroid follicular cells, and the feedback mechanisms along the HPT axis to gain insight into how dysregulated thyroid hormone signaling contributes to metabolic disturbances associated with hyperthyroidism Kohn et al

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The participants in the bariatric surgery study recruited at Bellvitge University Hospital were enrolled in a registered clinical trial (ISRCTN14104758, and the primary outcomes have been published in Casajoana et al