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GPR17 agonist treatment had no effect on GPBAR-A-stimulated cAMP levels in the control transduction condition, but there were modest MDL29,951 concentration-dependent increases in cAMP in cells expressing hGPR17L relative to vehicle treatment (Figure 6F)

This cross-species multi-model analysis strengthens the translational relevance of our findings by bridging mechanistic insight with clinical applicability

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Not if protein intake is adequate

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