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doi:10.1186/s12906-015-0560-4 Yan ST, Gao F, Dong TW, et al

It mobilizes fat, but it also raises insulin-like growth factor 1 (IGF-1), worsens insulin resistance, can drive fluid retention and carpal tunnel symptoms, and is implicated in tissue overgrowth at supraphysiologic doses

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By inhibiting NNMT, researchers can preserve NAD+ levels, enhance cellular energy capacity, promote fat utilization, and support metabolic healthall without exogenous NAD+ supplementation