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In addition, lifestyle interventions have been found to reduce neuroinflammation and improve mood by stimulating neuroplasticity and promoting the release of neurotrophic factors in the PFC, a region integral to emotional regulation, decision-making, and cognitive functions and particularly sensitive to inflammatory processes, which can disrupt neurotransmitter systems and contribute to the development of depressive symptoms [79,172,325,326,327,328,329]

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B12 deficiency produces a recognizable cluster of symptoms: fatigue, weakness, neurological changes including tingling or numbness in the extremities, cognitive fog, and in more severe cases, megaloblastic anemia