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Liver enzyme elevations (ALT and AST above 3 times the upper limit of normal) occurred at rates similar between orforglipron and placebo groups, with no dose-dependent pattern suggesting drug-related hepatotoxicity

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Animal studies show improvements in tissue regeneration, reduced inflammation, and enhanced organ function following senescent cell clearance [3] [5]

Bull Exp Biol Med 2003;135:5902

localised swelling, bruising, and discomfort at the injection site