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A study conducted in vivo, ex vivo, and in vitro showed that TMAO upregulated the expression of bone-associated molecules including Runx2 (Runt-related transcription factor 2) and BMP2 (bone morphogenetic protein 2), indicating that TMAO promoted osteogenic differentiation of vascular smooth muscle cells and that TMAO positively regulated vascular calcification, an effect that was mediated by TMAO through activation of NLRP3 inflammasome and NF-B signaling to promote vascular calcification

Amir, R., Ciechanover, A

When OCTN2 malfunctions, it can lead to Primary Carnitine Deficiency (PCD), a condition marked by widespread carnitine depletion and serious health issues, including fertility problems

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, autor principal de "Uma abordagem melhor para o tratamento da insuficincia de hormnio do crescimento de incio na idade adulta?", bacharel em farmcia pela Universidade Rutgers, mestre em bioqumica pela Universidade Estadual do Novo Mxico e doutor em fisiologia pela Universidade Rutgers