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If you're at risk of a B12 deficiency, you can usually take a supplement

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This is especially important when more than one person is caring for the patient, to prevent accidental repeat dosing

Glutathione synthetase deficiency is the most frequently recognized disorder and, in its severe form, it is associated with hemolytic anemia, metabolic acidosis, 5-oxoprolinuria, central nervous system (CNS) damage and recurrent bacterial infections

For example, most arsenic is cleared from the blood in a few hours, but the half-life of lead in bone approaches 30 years (1)