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Reverse electron transport is also associated with ROS generation at complex I

In this study, we examined the longevity of mice with isolated GH deficiency due to targeted disruption of the GHRH gene (GHRH-KO)

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CBS and CSE have been reported to re-localise to mitochondria in response to hypoxia, a common feature of the tumour microenvironment, resulting in targeted H 2 S delivery that can stimulate ATP production and protect mitochondria from oxidative stress

All protocols were approved by the Institutional Animal Care Committee at the University of British Columbia and conformed to the guidelines set out by the Canadian Counsel on Animal Care