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The 28-day limit comes from the manufacturer label and from United States Pharmacopeia (USP) guidance, not from a guess

Needless to say, I wouldn't ignore it at this stage but I would look for an explanation

Think of it less as a hard expiration date and more as a maximum safety window

This article explains the clinical principles behind reconstitution, the significant safety risks of self-administering unlicensed injectables, and why individuals considering retatrutide should seek guidance from a qualified healthcare professional before proceeding