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For instance, participants in clinical trials have experienced weight reductions of 15% or more, which can have profound effects on overall health, including reducing the risk of comorbidities associated with obesity

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Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs

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