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The greater decrease in LAC levels in severe forms of MDD and in patients with treatment resistant depression (TRD) is akin to a kindling-like progression of depression in that earlier age at onset and/or the presence of early life adversity, such as emotional trauma, conveys liability to more severe and treatment-resistant course of illness [51, 53, 55]

Results Human studies of critically ill patients suffering from sepsis During the first week in ICU, plasma concentrations of ACTH in patients were always lower than those of healthy controls ( p 0.05) (Fig

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Published pharmacokinetic data are most robust for this route, and the clinical track record is longest

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