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So Lv and associates formulated a ROS-sensitive nanocarrier to deliver the neuroprotective agent, i.e., NR2B9C at the stroke site in contrast to ischemic brain damage

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Astrocytes modulate diabetic BBB integrity via glial-derived neurotrophic factor, nitric oxide, tumor necrosis factor-, reactive oxygen-nitrogen, advanced glycation end-products, transforming growth factor-, glial cell line-derived neurotrophic factor, basic fibroblast growth factor, interleukin-6, steroids, the v5-integrin/glycogen synthase kinase-3/-catenin signaling pathway, and noncanonical hedgehog signaling