Key takeaways Black box warnings, or boxed warnings, are serious warnings that come from the FDA
Are both FDA-approved for obesity
However, clinical trials have shown its significant benefits for weight loss
Figure 1: Biological efects of GLP-1 on target tissues (Source: Frontiers in Endocrinology) Initially known primarily as a blood sugar regulator, GLP-1 is now recognized for its roles in treating diabetes, cardiovascular disease, Alzheimers, depression, kidney and liver diseases, and arthritis
Discussion In this database study, treatment with semaglutide (against sitagliptin, a placebo proxy) led to a reduced risk of MACE, and tirzepatide (against dulaglutide) demonstrated a similar risk reduction in patients at elevated cardiovascular risk with obesity and type 2 diabetes