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The present study revealed that both high-dose paraxanthine (PXN HIGH) and high-dose caffeine (CAF HIGH) significantly increased neurotransmitters involved in learning and memory, including acetylcholine, dopamine, and GABA

In the DELTA 1 and DELTA 2 phase 3 trials, delgocitinib cream (20 mg/g) applied twice daily significantly significantly improved IGA-CHE scores compared with vehicle, with 19.729.1% of patients achieving clear or almost clear skin, respectively, versus 6.99.9% in the vehicle groups [103, 106]