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On GLP-1 medication efficacy: The active ingredients that Direct Meds' compounded medications are based on, semaglutide and tirzepatide, have been studied extensively in large clinical trials of their FDA-approved versions

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SURMOUNT-1 enrolled people with obesity or overweight and no diabetes, and the weight reduction just kept climbing with the dose: about 15 percent at 5 mg, 19.5 percent at 10 mg, and a frankly striking 20.9 percent at 15 mg over 72 weeks