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Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats

Presence of GSH limits serine metabolism and maintains FoxP3 expression, necessary for T regulatory cell function [109], which would be important for preventing too much inflammation

Phosphorylation of the DSGIS motif in NRF2 mediated by glycogen synthase kinase-3 beta (GSK-3) promotes the binding of -TrCP to NRF2 which is therefore marked for ubiquitination and then degraded by the proteasome [145, 149,150,151]

This is something that drinking water alone cannot always achieve