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Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]

Supplementary material The Supplementary material for this article can be found online at: Glossary References 1 AlataW.YeY.St-AmourI.VandalM.CalonF

doi:10.1016/S0140-6736(23)00085-5

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