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For type 2 diabetes, your options include: DPP-4 inhibitors GLP-1 receptor agonists (Ozempic, Trulicity, Victoza) GLP-1/GIP receptor agonists (Mounjaro) SGLT2 inhibitors Thiazolidinediones And prescription weight-loss medications that are currently available include: Orforglipron, an oral small-molecule non-peptide GLP-1 receptor agonist ( Foundayo ) GLP-1/GIP receptor agonists ( Zepbound ) Phentermine-topiramate ( Qsymia ) Bupropion-naltrexone ( Contrave ) Your clinician, like those through Weight Watchers Med+ , can go over your available options and, if you qualify, prescribe medication and a lifestyle plan designed for your body and your goals.* Retatrutide warnings and precautions Despite the fact that retatrutide is not an approved medication, there is active marketing for medications being characterized as retatrutide. Because retatrutide is still investigational, there is no regulated manufacturing or supply chain, meaning you cannot be sure what you are actually receiving and putting in your body, says Rhodes

The next best-selling medication was a psoriasis treatment that brought in less than a third as much as Ozempic

Some users report no side effects

Food and Drug Administration for people with obesity or those who have complications from being overweight

Genetic Predispositions and Peptide Pathway Response Variation Clinical research identifies specific genetic variants in GLP1R, GIPR, and MC4R genes that correlate with GLP-1 response profiles