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The GSH administration lowered ROS production and lipid peroxidation, indicating reduced oxidative stress

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Neurological symptoms may take longer to resolveoften several weeks to monthsand improvement may be gradual rather than immediate

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Immunohistochemical analysis also revealed a significant decrease in the hepatic expression of both proapoptotic markers Bax and caspase-3 with significant increase in antiapoptotic Bcl-2 expression in rats treated with NTZ-200, NAC or 4-PBA when compared to MTX group (Figure 9)