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In humans, acute intravenous infusion of PYY(336) has consistently been shown to reduce hunger and food intake in a dosedependent manner (by approximately onethird), an effect observed in both lean and obese individuals (154)
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More precise quantification can be achieved through imaging modalities such as magnetic resonance imaging (MRI) or computed tomography (CT), though these are typically reserved for research settings or specific clinical indications due to cost and, in the case of CT, radiation exposure
During menopause, when hunger signals become less reliable and insulin resistance develops, semaglutide can help restore these regulatory pathways, making it easier to eat smaller portions and feel satisfied longer
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