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Case report data show salivary flow returning to normal within four weeks of stopping semaglutide

Consequently, this activation promotes the abundant secretion of pro-inflammatory cytokines, including interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-), thereby establishing and perpetuating a chronic inflammatory microenvironment (66)

Importantly, tirzepatide carries a boxed warning regarding thyroid C-cell tumors observed in rodent studies, though the relevance to humans remains uncertain

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