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If supplementation is indeed required, it must be preceded by a careful consideration of the patients Se baseline status, gender, weight and so on ( 3.3 Dual role of Se deficiency in cretinism Cretinism often occurs in areas where endemic goiter is prevalent, with mucinous edema cretinism being the main manifestation of hypothyroidism without goiter

KG can generate acetyl-CoA, a metabolic precursor for lipid synthesis in the cytoplasm, and stimulate dihydrolipoamide dehydrogenase to produce mitochondrial ROS and increase local iron levels to promote ferroptosis [45]

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