Frontiers in Pharmacology 7 : 433
Surely, we can practice lifestyle modifications to reduce the production of ROS, but there is no way to completely stop it
If oral delivery of triple agonists becomes possible with reasonable bioavailability, the injectable versus oral debate would shift significantly
Consequently, adipocyte numbers were not affected
Your body actually prefers to catabolize muscle over fat when calories are restricted because: Muscle is metabolically expensive (burns calories at rest) Your body "wants" to reduce calorie expenditure Evolutionary survival mechanism (preserve fat, reduce muscle) Gets worse as body fat drops below 12-15% for men, 20-25% for women The typical cutting disaster: Week 1-4: Lose 8 pounds (6 pounds fat, 2 pounds muscle) Week 5-8: Lose 6 pounds (4 pounds fat, 2 pounds muscle) Week 9-12: Lose 4 pounds (2 pounds fat, 2 pounds muscle) Result: Lost 18 pounds total, but 6 pounds was muscle You're lighter but not necessarily leaner Strength dropped significantly Metabolism crashed This is where most people fail
