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While, post-treatment regulated the oxidant/antioxidant balance and neutralized the toxic side effects caused by Amethopterin induced oxidative stress

A critical target is the voltage-dependent anion channel (VDAC), which regulates the exchange of ions and metabolites across the outer mitochondrial membrane

Interestingly, research on the Na + -dependent glutathione transporter for brain targeting has been limited despite the fact that the glutathione transporter is selectively distributed in the brain, kidneys, and small intestine

In situations where the damage is severe, you might want to consider stem cell therapy instead