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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimers disease

Specially, the pro-survival pathway PI3K/Akt directly affects the expression of key ferroptosis-related proteins, such as GPX4, SLC7A11, Nrf2, and ACSL4, thereby affecting ferroptotic metabolism ( 4 Effects of plant polysaccharides on cancer treatment via ferroptosis Polysaccharides possess significant anticancer potential by inhibiting cancer cell growth, regulating immunity, improving the cancer microenvironment, and overcoming drug resistance

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Zhou, X., Matavelli, L