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Int J Mol Med (2018) 41(5):297785

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Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

While this was an early observational study, the results suggest that GLP-1 receptor agonists may offer an additional therapeutic consideration in this difficult-to-treat population and may help inform clinical decision-making in real-world practice, Fu said