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370 In hyperglycemic states, changes in the metabolic pathways of sugar (increased flux of the hexosamine pathway, increased flux of the polyol pathway, decreased flux of pentose phosphate and glycolytic pathways) lead to decreased production of NADPH and increased ROS, exacerbating oxidative stress

by food, then hepatic extraction is more effective and less ethanol reaches the systemic circulation

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Continued mechanism-based studies in human stubjects are also needed to determine the relevance of putative antioxidant or pro-oxidant effects for cancer prevention in humans

Data are estimated mean (CI) changes from the estimated baseline value in UACR, analysed using a mixed model for repeated measurements