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Causes: oversupplementation Clinical features In infants: increased risk of necrotizing enterocolitis (NEC) High-dose supplementation: alteration of vitamin K metabolism anticoagulatory effects of warfarin risk of bleeding Increased incidence of heart failure, subarachnoid hemorrhage, and increased mortality [10] Therapeutic uses Nonalcoholic steatohepatitis: consider vitamin E for antioxidant effect Characteristics Synonyms Vitamin K 1 (phytomenadione, phytonadione, or phylloquinone) Vitamin K 2 (menaquinone) Substance class: naphthoquinones Chemical structure: Vitamin K1 Vitamin K2 Inactive precursors (provitamins): none Active form: vitamin K hydroquinone Sources Leafy green vegetables (vitamin K 1 ) Eggs, dairy, and meat (vitamin K 2 ) Synthesized in small amounts by intestinal bacteria Transport: via lipoproteins

Liu BD, et al

GHK-Cu can be applied topically though penetration is limited

It may occur because the medication helps the patient feel full sooner and slows digestion

Blood Disorders 2011