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A complex gut-brain relationship is evident, as satiety is influenced by GLP-1R activation present in both the central nervous system while the intestine is further modulated by vagal cholinergic signals

On a more surface level, these skin changes might look like a general aging of the skin, thats not always full-on Ozempic face: People who are on GLP-1s have got new fine lines and wrinkles, brown spots, textural changes and roughness, and just have lost that glow, says Ava Shamban, MD, a board-certified dermatologist in Los Angeles

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