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Cystine is then imported into the cell via system Xc , where the SLC7A11 subunit plays a critical role in maintaining redox homeostasis due to its specificity for transporting cystine and glutamate and SLC3A2 acts as a molecular chaperone that stabilizes SLC7A11 at the plasma membrane
49 GhadgeA
Common targets include glutamate/NMDAR overactivity, undermethylation, copper-zinc imbalance, histamine, pyroluria, oxidative stress, toxic burden, and gut inflammation
The gut and the brain
Notably, while S1PR2 is upregulated and induces the internalization of meningococci, the activation of S1PR1 or S1PR3 reduces the number of intracellular bacteria (Fohmann et al., 2023)
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