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Koeth R, Culley M, Wang Z, Nemet I, Kirsop J, Org E, et al

Further experiments validated that the downregulation of xCT expression suppresses the promoting effect of cancer cell death under nutritional deficiency [58]

Currently, there are several strategies for overcoming chemoresistance in cancer, including discontinuous dosing, modifying drug concentrations, combination therapy, and the use of natural products ( In this review, we aim to understand the mechanisms of chemotherapy resistance in GC and to explore the potential of TCM and its active components as chemotherapy sensitizers in reversing chemotherapy resistance and improving curative effect in GC

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Astragalus polysaccharide inhibits the development of urothelial carcinoma by activating AMPK signaling to induce BENC1-xCT complex formation