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However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans

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The critical variable is whether the specific pharmacy can provide lot-level documentation particularly the benzyl alcohol assay and sterility confirmation for the product currently in distribution

Conflict of interest The authors declare no conflict of interests

Human arterial endothelial cell detachment in vitro : Its promotion by homocysteine and cysteine