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In addition, NRF2 activation was found crucial for the reprogramming of induced pluripotent stem cell (iPSC), which was known to be an inefficient process and required the metabolic shift from the oxidative phosphorylation to glycolysis as a major way to generate ATP

Psychiatry 92 , 510518 (2021)

In the study of endometrial cancer (EC), we found that Brusatol sensitizes the cancer to progestins by inhibiting the NRF2-TET1-AKR1C1 pathway, which reduces AKR1C1 expression and decreases progesterone metabolism [110]

A., Hartmann, K

(1998) Effects of low-dose recombinant human insulin-like growth factor-I on insulin sensitivity, growth hormone and glucagon levels in young adults with insulin-dependent diabetes mellitus