Abbreviations ATC: anaplastic thyroid carcinoma AP: apurinic/apyrimidinic or abasic APE1: apurinic/apyrimidinic endonuclease 1 BER: base excision repair GSH: glutathione TME: tumor micro-environment AP probe-net: AP sites capture reagent WB: western blotting RIT: radioiodine therapy DNS: 2,4-dinitrobenzene sulfonamides MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide RMPI 1640: Roswell park memorial institute 1640 FBS: fetal bovine serum DMSO: dimethyl sulfoxide TBST: tris-buffered saline Tween GSS: glutathione enzyme DSBs: double-strand breaks NSCLC: non-small cell lung cancer References Lorimer C, Cheng L, Chandler R, Garcez K, Gill V, Graham K, et al
Both peptides have accumulated substantial research documentation demonstrating regenerative effects across multiple tissue types and injury models
This complementary mode of action suggests that the simultaneous use of Azelaic Acid and Tretinoin can lead to combined benefits for certain skin concerns
Huang H, Chen K, Zhu Y, Hu Z, Wang Y, Chen J, et al
Nat Rev Mol Cell Biol 25(1):4664
