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The Glucagon Paradox in Next-Generation Incretin Therapy: How GLP-1, GIP, and Glucagon Receptor Co-Agonism May Amplify Weight Loss Despite Glucagons Hyperglycemic Biology Abstract The development of dual and triple incretin-based receptor agonists represents a major advance in the pharmacologic treatment of obesity, type 2 diabetes, and related cardiometabolic disease

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Mol Cell (2008) 30:21426.10.1016/j.molcel.2008.03.003 171 GreerELOskouiPRBankoMRManiarJMGygiMPGygiSPet alThe energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

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