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Phentermine increases heart rate and blood pressure through sympathomimetic activity, while GLP-1 agonists have shown mixed cardiovascular effectsbenefits in diabetic populations but potential concerns in certain patient subgroups, particularly those with a history of thyroid cancer or multiple endocrine neoplasia

For patients with type 2 diabetes, that difference in glucose control translates to meaningful clinical outcomes over time

Whilst exendin-4-C16 showed minimal reduction in cAMP signalling potency, marked differences were observed for recruitment of key intracellular effectors and trafficking responses, which led to increased insulin secretion with prolonged incubations

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