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The use of metformin in patients with gestational diabetes mellitus affects the composition and metabolic characteristics of the gut microbiota, particularly the metabolic pathways related to CoQH 2 biosynthesis [123]

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In mouse models of DMD, it has been found that IGF1-LR3 and other IGF-1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis