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Preclinical research means studies conducted in animal models and laboratory settings

Serving Size: 1 mL (2 Pumps)

[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Kadri R., Shetty A., Parameshwar D., Kudva A.A., Achar A., Shetty J

Whether chronic morphine exposure induces constitutive activity of MOR, or whether this is widespread in the nervous system is therefore still uncertain, but if correct, the observation that constitutive MOR activity increases after chronic opioid exposure suggests an active confomational state of MORs that is evident even in the absence of bound ligand

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