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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Higgins J.P., Liras G.N., Liras I.N

11% of US adults are on a GLP-1 for weight loss (up from 3% just 2 years ago)

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chronic, maintenance of weight balance Synergy with leptin , amylin restores leptin sensitivity in obese models Synergy with CCK and GLP-1 , multi-pulse pathways of appetite suppression No tolerance , chronic administration of amylin preserves efficacy Why it matters: Lutzs review article established the scientific basis for amylin pharmacotherapy of obesity

Proc Natl Acad Sci USA 2000