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1.5 g of Cinnamon treatment for 8 weeks to PCOS patients significantly inhibited serum fasting blood glucose, insulin, HOMA-IR, total cholesterol and LDL-cholesterol, but increased HDL-cholesterol compared to placebo group [121]

At the tumor level, high iron demand due to rapid proliferation, upregulation of transferrin receptor 1, and downregulation of ferroportin promote iron sequestration within tumor cells, reducing circulating iron (137)

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