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These alterations are closely linked to subtle changes in glomerular filtration barrier permeability and impaired OCTN2-mediated tubular reabsorption, reflecting an early breakdown of the filtration, reabsorption, redistribution balance of carnitine metabolism

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This structural relationship has made Dihexa useful for comparative investigations of angiotensin-derived compounds, structure-activity relationships, peptide-derived signaling modulators, and the molecular determinants governing receptor-associated signaling pathways.