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Emerging strategies focus on mitochondrial-specific antioxidants (e.g., MitoQ, SS-31), which have shown promise in preclinical and early-phase clinical trials by reducing mtROS and improving endothelial function in diabetic patients (Mason et al., 2022)

A proportion of pyruvate undergoes reduction to lactate, but the majority enters the mitochondria for further processing in the TCA cycle for eventual oxidative phosphorylation, which enables energy production

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ALDH2 (aldehyde dehydrogenase 2) protects against hypoxia-induced pulmonary hypertension

Researchers believe that not only will attention to proper diet improve their health, but it can also benefit sleep, psychiatric state and response to medication (x)