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Therefore, based on the current findings showing a downregulation in NTS PPG expression by HFSD diet induced obesity, it is tempting to speculate that this effect might exacerbate or perpetuate a chronic hyperphagic effect that sustains obesity

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Genetic testing through the Precision Peptide Genetic Test can reveal whether your GLP1R receptor variant predisposes you to lower responsiveness to semaglutide specifically, which would suggest tirzepatide or a dual-agent approach as a better fit

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