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Cellular antioxidant systems eliminating lipid peroxidation of membrane phospholipids mainly function through the system Xc - /GPX4 axis (B) and other parallel metabolic pathways, including the FSP1/CoQ 10 /NADPH system, mitochondria DHODH/CoQH 2 system, and GCH1/BH4/DHFR system (C)

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