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Differences in blood sugar control For people with type 2 diabetes, tirzepatide also showed better results for improving blood sugar levels: In a head-to-head trial directly comparing the two medications, tirzepatide (15mg dose) reduced A1C by about 2.3 percentage points, while semaglutide (1mg dose) reduced it by 1.86 points an additional 0.45% reduction with tirzepatide

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That is the mechanistic rationale for the 24.2% mean weight loss seen at 48 weeks in the Phase 2 obesity cohort [11]