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Overall, NRF2 plays a crucial cellular protective role through the sensing of oxidative stress, nuclear translocation, binding to AREs, and the regulation of the expression of antioxidant and detoxification enzymes

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In mammalian brain, Glu is by far the most prevalent neurotransmitter, which is excitatory working on over 90% of the synapses in the brain 72

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Exploring the molecular mechanisms underlying ferroptosis and identifying related signaling pathways in various kidney diseases will also elucidate new targets and directions for the research and development of kidney disease drugs