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The Numbers That Matter: In the landmark SURMOUNT-5 trial published in the New England Journal of Medicine in May 2025, participants taking tirzepatide lost an average of 20.2% of their body weight over 72 weeks, compared to 13.7% with semaglutide

Within this timeframe, research has often shown good tolerability when appropriate doses are used and proper tracking is used

Discover factors that influence how quickly it works and what to expect during treatment

These hormones can cause your blood sugar to rise, making it harder for your medications to keep things stable

It can also be broken down by catalases (CAT), enzymes that protect the cell from the oxidizing and harmful action of hydroperoxide (see 2.4)